Anti-inflammatory, anti-bronchoconstrictor drug
Active substance
Release form, composition and packaging
film-coated tablets, white, round, biconvex.
Excipients: calcium hydrogen phosphate - 104.5 mg, hypromellose - 100 mg, povidone-K30 - 12.8 mg, anhydrous colloidal silicon dioxide - 0.5 mg, magnesium stearate - 2.2 mg.
Shell composition: titanium dioxide - 0.841 mg, glycerol - 0.263 mg, hypromellose - 4.37 mg, macrogol 6000 - 0.263 mg, magnesium stearate - 0.263 mg.
15 pcs. - blisters (2) - packs of cardboard with the control of the first opening (if necessary).
pharmachologic effect
Pharmacodynamics
The anti-inflammatory and anti-bronchoconstrictor activity of fenspiride is due to a decrease in the production of a number of biologically active substances (cytokines (especially TNFα), arachidonic acid derivatives, free radicals), which play an important role in the development of inflammation and bronchospasm.
Inhibition of arachidonic acid metabolism by fenspiride is potentiated by its H 1 -antihistamine action, tk. histamine stimulates the metabolism of arachidonic acid with the formation of prostaglandins and leukotrienes. Fenspiride blocks α-adrenergic receptors, the stimulation of which is accompanied by an increase in the secretion of bronchial glands. Thus, fenspiride reduces the effect of a number of factors that contribute to the hypersecretion of pro-inflammatory factors, the development of inflammation and bronchial obstruction.
Fenspiride also has an antispasmodic effect.
Pharmacokinetics
Suction
After oral administration, Cmax is reached after 6 hours.
breeding
T 1/2 - 12 hours. Excreted mainly by the kidneys.
Indications
Diseases of the upper and lower respiratory tract:
- rhinopharyngitis and laryngitis;
- tracheobronchitis;
- bronchitis (against the background of chronic respiratory failure or without it);
- hypersensitivity to the active substance and / or any of the components of the drug.
Dosage
Adults the drug is prescribed 80 mg (1 tab.) 2-3 times / day.
The maximum daily dose is 240 mg. The duration of treatment is determined by the doctor.
Side effects
The patient should be informed of the need to inform the doctor about any, incl. undesirable reactions and sensations not mentioned below, as well as changes in laboratory parameters during therapy with Erespal.
The most common adverse reactions to Erespal are observed in the digestive system.
The frequency of adverse reactions that may occur during therapy is given as the following gradation: very often (> 1/10); often (>1/100,<1/10); нечасто (>1/1000, <1/100); редко (>1/10 000, <1/1000); очень редко (<1/10 000); неустановленной частоты (частота не может быть подсчитана по доступным данным).
From the side of the cardiovascular system: rarely - moderate tachycardia, the severity of which decreases with a decrease in the dose of the drug; unspecified frequency * - a feeling of palpitations and a decrease in blood pressure, possibly associated with tachycardia.
From the digestive system: often - gastrointestinal disorders, nausea, epigastric pain; unspecified frequency * - vomiting.
From the side of the central nervous system: rarely - drowsiness; unknown frequency * - dizziness.
From the skin and subcutaneous fat: rarely - erythema, rash, urticaria, angioedema, fixed pigmentary erythema; unspecified frequency * - pruritus, toxic epidermal necrolysis, Stevens-Johnson syndrome.
General disorders: unspecified frequency * - asthenia, increased fatigue.
* Post-registration data.
Overdose
In case of an overdose of the drug (cases of overdose have been noted when taking the drug at a dose of more than 2320 mg), you should immediately seek medical help.
Symptoms: drowsiness or agitation, nausea, sinus tachycardia.
Treatment: gastric lavage, ECG monitoring, maintenance of vital body functions.
drug interaction
Special studies on the interaction of fenspiride with other drugs have not been conducted.
Due to the possible sedative effect when taking histamine H1 receptor blockers, the use of Erespal in combination with drugs that have a sedative effect, or in conjunction with alcohol, is not recommended.
special instructions
For treatment children and adolescents under the age of 18 Erespal syrup should be used.
Influence on the ability to drive vehicles and control mechanisms
Studies to study the effect of the drug Erespal on the ability to drive vehicles and work with mechanisms have not been conducted. Patients should be aware of the possible development of drowsiness when taking Erespal, especially at the beginning of therapy or when combined with alcohol intake, and should be careful when driving vehicles and performing work that requires a high speed of psychomotor reactions.
Pregnancy and lactation
There are no or limited data on the use of Erespal in pregnant women. The use of the drug during the time is not recommended.
Colds are perhaps the most common among the population. During the year, they can overtake repeatedly, be accompanied by various symptoms and complications, so treatment should not be postponed. In this case, Erespal comes to the rescue - a syrup that doctors often prescribe, both for young patients and adults.
The pharmacy range of drugs prescribed for acute respiratory infections is very wide. Relatively new and already proven effective among them is "Erespal" - a drug produced in tablets or syrup.
Fenspiride, which is part of Erespal, is the main active substance, thanks to which the medicine shows its complex medicinal properties. Tablets and syrup have slightly different composition, however, common pharmacological effects.
But the liquid form contains a number of advantages over the tablet:
- rapid absorption in the gastrointestinal tract;
- faster result;
- ease of use and dosing, which is important if the drug is prescribed for children;
- pleasant taste.
Erespal in syrup is available in a plastic container with a lid with a capacity of 150 ml. Outwardly - an orange-colored liquid with a slight vanilla aroma. Before using the syrup, it is recommended to shake it well, since the sediment at the bottom is a variant of the norm.
Pharmacological properties and pharmacokinetics
Fenspiride has a complex effect on the body:
- relieves inflammation;
- exhibits anti-exudative action;
- does not allow the development of bronchospasm;
- inhibits the action of histamine receptors, reducing allergic manifestations.
In the gastrointestinal tract, Erespal is absorbed quite well, reaching a maximum concentration after 6 hours, but reducing it by a factor of 12. It is excreted from the body naturally - with urine and through the intestines.
What kind of cough is Erespal syrup prescribed for?
Cough itself is not a disease! And the patient should be treated not for cough, but for the disease of which he is a symptom. Coughing is often a reflex to clear the airways. With acute respiratory infections with lesions of the upper and lower respiratory tract, it is the cough that helps to free them from sputum.
Erespal is prescribed for such diagnoses as:
- sinusitis (bacterial and viral);
- pharyngitis;
- laryngitis.
Syrup intake cannot be a complete replacement for antibiotic therapy. Therefore, Erespal is used as a component of complex treatment.
The use of fenspiride for otitis media, rhinitis (including those of allergic origin) and other ENT diseases, both accompanied and not accompanied by cough, is justified.
The anti-inflammatory effect of Erespal syrup leads to a decrease in exudation, removal of edema of the bronchial mucosa, and liquefies sputum. The effectiveness of Erespal has been clinically proven in both dry and wet cough, which occurs against the background of inflammatory respiratory diseases.
As a cough syrup, Erespal can be prescribed for whooping cough. This dangerous disease is most common among children under 2 years of age. Whooping cough is caused by special aerobic bacteria, while a person does not have innate immunity to them. And even vaccination, which significantly reduces the risk of infection, does not provide complete protection against whooping cough. Erespal in this case does not relieve the disease, but significantly alleviates the patient's condition, reducing the severity of a severe and debilitating cough. Bronchial asthma is another disease in which the drug can be prescribed. A characteristic symptom of asthma is bronchial obstruction - a narrowing of their lumen, which is manifested by shortness of breath and coughing. Due to the action of fenspiride, the lumen of the bronchi increases, the risk of mucus stagnation decreases. Therefore, it is advisable to use Erespal for bronchitis, chronic pulmonary obstruction.
Instructions for use and dosage of the drug
Erespal tablets are not prescribed for children! Syrup, on the other hand, is prescribed to small patients in the exact dosage that must be observed. For adults, the liquid form of the drug is also possible for use.
Erespal syrup for children
Kids quite easily agree to be treated with Erespal due to its pleasant taste and smell. The smallest - up to two years, Erespal is not assigned at all. In other cases, the instructions for use regulate the following dosage: 4 mg of the drug for each kilogram of the baby's weight during the day, that is, the daily rate of the drug can be given in 2 doses. This is done before meals, the bottle is shaken well beforehand.
On average, it takes:
- 10-20 ml (similar to 2-4 teaspoons) of syrup per day for children weighing up to 10 kg;
- 30-60 ml (from 2 to 4 tablespoons) Erespal for children weighing more than 10 kg.
In the presence of certain indications, at the discretion of the attending physician, a different dosage is possible. The duration of use of the drug is also determined by a specialist.
Erespal for adults
Adult patients and children from 12 years of age take 3-6 tablespoons in a daily volume (which is equivalent to 50-90 ml). In terms of fenspiride, 1 tablespoon of syrup (15 ml) contains 10 mg of the active substance.
Can I use the drug during pregnancy and lactation
During pregnancy or breastfeeding a baby, medicines for a woman are selected very carefully. The weeks of the first trimester are considered especially dangerous, since at this time the fetal organs are laid. Chemical and even plant components of drugs can have a negative impact on this process. And during the period of breastfeeding, substances are able to penetrate into milk, causing allergies or problems with breathing, digestion and the work of the central nervous system in the baby.
Erespal syrup is not intended for use as a medicine for expectant and nursing mothers.
However, with caution in some cases, it can be prescribed if the benefits for the mother outweigh the negative impact on the child, and the attending physician adequately assesses the potential risk.
Drug interactions with other drugs
Special studies on the interaction of Erespal with other drugs have not been conducted. At the moment, no compatibility has been identified. There are suggestions that the combined use of fenspiride-containing and sedatives enhances the effect of the latter. It is not recommended to combine treatment and alcohol intake. A negative result of such a joint use may be a deterioration in well-being, weakness, lethargy and drowsiness.
Contraindications, side effects and overdose
Erespal syrup for children and adult patients is considered a safe and effective drug. However, it also has contraindications for use.
Among them:
- intolerance to fenspiride and other components that make up the composition;
- age of children up to 24 months;
- diabetes mellitus: the drug contains sucrose - up to 0.9 bread units per tablespoon.
In addition, the medicine contains parabens in its composition. They are considered potential allergens, the effect of which can manifest itself only after a fairly long time.
The most common side effects from taking standard drugs are: difficulty in digestion, nausea, heart palpitations, drowsiness, or, conversely, sleep disturbance. An overdose of syrup is manifested by similar adverse reactions. If the prescribed rate of the drug is exceeded, the victim should wash the stomach, if you feel worse, call an ambulance or seek medical help yourself. Treatment is symptomatic, in some cases an ECG, drug treatment, and support for the vital functions of the body may be required.
Erespal syrup analogs
Erespal does not have an absolute analogue in terms of active ingredients. The syrup is produced by the French company Servier Laboratories, as well as the representative company in Russia, Pharmstandard-Leksredstv, in the city of Kursk. Erespal's analogues are selected by the doctor, taking into account the individual characteristics of the patient.
It can be:
- Siresp is a syrup with fenspiride in the composition, which has anti-inflammatory and bronchodilator properties. It has the same contraindications. Dosages are similar, taking into account the age and weight of patients.
- Sinekod (drops) is a strong drug that suppresses the activity of the cough receptor. The active substance of Sinekod is Butamirat, these drops can only be taken with a dry cough. Allowed for babies from 8 weeks of age.
- Ascoril is a syrup that allows you to quickly alleviate the patient's condition with a debilitating cough, which has a complex therapeutic effect. It has a complex composition, where the active ingredients are guaifenesin, bromhexine and salbutamol. Ascoril is indicated for small patients from 6 years of age.
- Ambrobene is a syrup containing Ambroxol, it effectively dilutes and removes sputum, promotes accelerated recovery from respiratory tract infections. Ambrobene is prescribed for children from 2 years of age.
- Lazolvan is a syrup prescribed for coughing with sputum that is difficult to pass, which is based on ambroxol. Not suitable for oral use in children under 2 years of age.
- Stoptussin-phyto is a cough syrup based on guaifenesin and butamirate. The drug simultaneously splits sputum and partially blocks the cough center, which is good for an unproductive dry cough.
- Cashnol is a remedy in the form of a liquid syrup with the active ingredients salbutamol and bromhexine. Assign to patients from 6 years old as a mucolytic and expectorant.
Any remedy that is supposed to be given to a child for coughing should be discussed with the attending physician. In the absence of a visible effect when taking Erespal after a week of use, you should also contact a specialist and discuss further treatment.
Laboratories Servier Industry Laboratories Servier Industry / Serdiks, LLC Laboratories Servier / Laboratories Servier Industry Serdiks, OOO Pharmstandard-Leksredstva OAOCountry of origin
Russia France France/RussiaProduct group
Respiratory systemDrug with anti-inflammatory and anti-bronchoconstrictor activity
Release form
- 15 - blisters (2) - packs of cardboard. upak 30 tablets bottle 150 ml bottle 250 ml in cards. pack
Description of the dosage form
- Syrup Syrup orange, clear; possible formation of a precipitate that disappears when shaken Tablets, film-coated white, round, biconvex. film-coated tablets
pharmachologic effect
The anti-inflammatory and anti-bronchoconstrictor activity of fenspiride is due to a decrease in the production of a number of biologically active substances (cytokines, especially tumor necrosis factor alpha (TNF-alpha), arachidonic acid derivatives, free radicals), which play an important role in the development of inflammation and bronchospasm. Inhibition of arachidonic acid metabolism by fenspiride is potentiated by its H1-antihistamine action, tk. histamine stimulates the metabolism of arachidonic acid with the formation of prostaglandins and leukotrienes. Fenspiride blocks alpha-adrenergic receptors, the stimulation of which is accompanied by an increase in the secretion of bronchial glands. Thus, fenspiride reduces the effect of a number of factors that contribute to the hypersecretion of pro-inflammatory factors, the development of inflammation and bronchial obstruction. Fenspiride also has an antispasmodic effect.Pharmacokinetics
Well absorbed from the gastrointestinal tract. The maximum plasma concentration after oral administration is reached after 2.3 ± 2.5 hours (from 0.5 to 8 hours). The half-life is 12 hours. It is excreted mainly by the kidneys (90%), through the intestines 10%.Special conditions
The composition of the drug in the form of a syrup includes parabens (parahydroxybenzoates), as a result, taking this drug can provoke the development of allergic reactions, incl. delayed. When prescribing the drug to patients with diabetes, it should be taken into account that Erespal® syrup contains sucrose (1 teaspoon - 3 g of sucrose = 0.3 XE; 1 tablespoon - 9 g of sucrose = 0.9 XE). Influence on the ability to drive vehicles and control mechanisms Studies on the effect of the drug Erespal® on the ability to drive vehicles and work with mechanisms have not been conducted. Patients should be aware of the possible development of drowsiness when taking Erespal®, especially at the beginning of therapy or when combined with alcohol intake, and should be careful when driving vehicles and performing work that requires a high speed of psychomotor reactions. Overdose In case of an overdose of the drug (there have been cases of overdose when taking the drug at a dose of more than 2320 mg), the patient should immediately seek medical help. Symptoms: drowsiness or agitation, nausea, vomiting, sinus tachycardia. Treatment: gastric lavage, ECG monitoring, maintenance of vital body functions.Compound
- 1 tab. Fenspiride hydrochloride 80 mg Excipients: calcium hydrogen phosphate, hypromellose, povidone, anhydrous colloidal silicon dioxide, magnesium stearate. The composition of the film shell: titanium dioxide, glycerol, hypromellose, macrogol 6000, magnesium stearate. 100 ml fenspiride hydrochloride 200 mg Excipients: flavoring composition with hints of honey smell - 500 mg, licorice root extract - 200 mg, vanilla tincture - 400 mg, glycerol - 22.5 g, sunset yellow dye (sunset yellow S) - 10 mg, methyl parahydroxybenzoate - 90 mg, propyl parahydroxybenzoate - 35 mg, saccharin - 45 mg, sucrose - 60 mg, potassium sorbate - 190 mg, purified water - up to 100 ml. fenspiride hydrochloride - 0.2 g. Excipients: flavoring composition with hints of honey smell 0.500 g, licorice root extract 0.200 g, vanilla tincture 0.400 g, glycerol 22.5 g, sunset yellow dye (Sunset yellow S) 0.01 g , methyl parahydroxybenzoate 0.09 g, propyl parahydroxybenzoate 0.035 g; saccharin 0.045 g, sucrose 60.0 g, potassium sorbate 0.19 g; purified water up to 100 ml
Erespal indications for use
- Diseases of the upper and lower respiratory tract: - nasopharyngitis and laryngitis; - tracheobronchitis; - bronchitis (with or without chronic respiratory failure); - bronchial asthma (as part of complex therapy); - respiratory phenomena (cough, hoarseness, sore throat) with measles, whooping cough, influenza; - infectious diseases of the respiratory tract, accompanied by a cough, when standard antibiotic therapy is indicated. Otitis and sinusitis of various etiologies.
Overdose
Symptoms: drowsiness or agitation, nausea, vomiting, sinus tachycardia. Treatment: gastric lavage, ECG monitoring, maintenance of vital body functions.Storage conditions
- keep away from children
Dosage form:
syrupCompound:
100 ml syrup contains active substance: fenspiride hydrochloride - 0.2 g.Excipients: flavoring composition with hints of honey smell 0.500 g, licorice root extract 0.200 g, vanilla tincture 0.400 g, glycerol 22.5 g, sunset yellow dye (Sunset Yellow S) 0.01 g, methyl parahydroxybenzoate 0.09 g, propyl parahydroxybenzoate 0.035 g; saccharin 0.045 g, sucrose 60.0 g, potassium sorbate 0.19 g; purified water up to 100 ml.
Description
Transparent liquid of orange color, formation of the deposit disappearing at agitation is possible.
Pharmacotherapeutic group
Anti-inflammatory, anti-bronchoconstrictor agent.
ATX code: R03DX03
PHARMACOLOGICAL PROPERTIES
Pharmacodynamics
Anti-inflammatory agent, has an anti-exudative effect, prevents the development of bronchospasm. Shows antagonism with inflammation and allergy mediators: serotonin, histamine (blockade of H1-histamine receptors), bradykinin. It has a myotropic antispasmodic effect.
When administered in high doses, it reduces the production of various inflammatory factors (cytokines, arachidonic acid derivatives, free radicals).
Pharmacokinetics
Well absorbed from the gastrointestinal tract.
The maximum plasma concentration after oral administration is reached after 2.3 ± 2.5 hours (from 0.5 to 8 hours). The half-life is 12 hours.
It is excreted mainly by the kidneys (90%), through the intestines 10%.
INDICATIONS
Diseases of the upper and lower respiratory tract:
- Rhinopharyngitis and laryngitis;
- Tracheobronchitis;
- Bronchitis (with or without chronic respiratory failure);
- Bronchial asthma (as part of complex therapy);
- Respiratory effects (cough, hoarseness, sore throat) with measles, whooping cough and influenza;
- In infectious diseases of the respiratory tract, accompanied by a cough, when standard antibiotic therapy is indicated.
CONTRAINDICATIONS
Hypersensitivity to the active substance and / or any of the components of the drug.
Children's age up to 2 years.
CAUTION:
Patients with fructose intolerance, glucose-galactose malabsorption, sucrase / isomaltase deficiency (due to the presence of sucrose in Erespal ® syrup), patients with diabetes mellitus (due to the presence of sucrose in Erespal ® syrup).
PREGNANCY AND BREASTFEEDING
Taking the drug during pregnancy is not recommended.
Therapy with fenspiride is not a basis for terminating an ongoing pregnancy.
There are no clinical data on the fetotoxic effect of fenspiride or its ability to cause malformations when taken during pregnancy.
Erespal should not be used during breastfeeding due to the lack of data on the penetration of fenspiride into breast milk.
METHOD OF APPLICATION AND DOSES
STRICTLY FOLLOW YOUR PHYSICIAN'S ADVICE.
inside.
Shake before use.
Adults and teenagers:
From 3 to 6 tablespoons of syrup (45 - 90 ml) per day, taken before meals.
Children from 2 years old:
The recommended dose is 4 mg/kg/day.
- body weight up to 10 kg: 2 to 4 teaspoons of syrup per day (or 10 to 20 ml), can be added to a feeding bottle
- body weight more than 10 kg: 2 to 4 tablespoons of syrup per day (or 30 - 60 ml), taken before meals
1 tablespoon (15 ml of syrup) contains 30 mg of fenspiride hydrochloride and 9 g of sucrose.
1 teaspoon (5 ml of syrup) contains 10 mg of fenspiride hydrochloride and 3 g of sucrose.
The duration of treatment is determined by the doctor.
SIDE EFFECT
INFORM YOUR DOCTOR ABOUT THE APPEARANCE OF ANY, INCLUDING, NOT MENTIONED IN THIS INSTRUCTIONS, ADVERSE REACTIONS AND FEELINGS, AND ALSO ABOUT CHANGES IN LABORATORY INDICATORS DURING THE BACKGROUND OF THERAPY.
The frequency of adverse reactions that may occur during therapy is given as the following gradation: very often (> 1/10); often (>1/100, 1/1000, 1/10000, From the side of the cardiovascular system
Rarely: moderate tachycardia, the severity of which decreases with a decrease in the dose of the drug.
From the digestive system
Often: gastrointestinal disorders, nausea, epigastric pain.
Unset frequency: diarrhea, vomiting.
From the side of the central nervous system
Rarely: drowsiness.
Unset frequency: dizziness.
General disorders and symptoms
Unset frequency: asthenia, increased fatigue.
From the side of the skin and subcutaneous fat
Rarely: erythema, rash, urticaria, angioedema, fixed erythema pigmentosa.
Unset frequency: skin itching.
The risk of developing hypersensitivity reactions to the dye Sunset yellow S, which is part of the drug.
OVERDOSE
In case of an overdose of the drug (cases of overdose have been noted when taking the drug at a dose of more than 2320 mg), you should immediately seek medical help.
Symptoms: drowsiness or agitation, nausea, vomiting, sinus tachycardia.
Treatment: gastric lavage, electrocardiogram (ECG) monitoring.
Maintaining the vital functions of the body.
INTERACTION WITH OTHER DRUGS
Special studies on the interaction of fenspiride with other drugs have not been conducted.
Due to the possible increase in the sedative effect when taking histamine H1-receptor blockers, it is not recommended to use Erespal ® syrup in combination with drugs that have a sedative effect, or in conjunction with alcohol.
SPECIAL INSTRUCTIONS
The composition of the drug includes parabens (parahydroxybenzoates), as a result of which the use of this drug may provoke the development of allergic reactions, including delayed ones.
When prescribing the drug to patients with diabetes, it should be taken into account that Erespal ® syrup contains sucrose (1 teaspoon - 3 g of sucrose = 0.3 XE; 1 tablespoon - 9 g of sucrose = 0.9 XE).
Studies to study the effect of the drug Erespal ® on the ability to drive vehicles and work with mechanisms have not been conducted. Patients should be aware of the possible development of drowsiness when taking Erespal ®, especially at the beginning of therapy or when combined with alcohol intake, and should be careful when driving vehicles and when performing work that requires a high speed of psychomotor reactions.
RELEASE FORM
Syrup 2 mg/ml. 150 ml of syrup in a plastic bottle (PVC) of brown color with a plastic cap with control of the first opening. One vial with instructions for medical use is placed in a cardboard box.
STORAGE CONDITIONS
Special storage conditions are not required.
Keep out of reach of children.
BEST BEFORE DATE
3 years.
DO NOT USE AFTER THE EXPIRY DATE STATED ON THE PACKAGING.
HOLIDAY CONDITIONS
On prescription.
The registration certificate was issued to Servier Laboratories,
France, produced by Laboratories Servier Industry, France
Servier Industry Laboratories:
905, Highway Saran, 45520 Gidi, France
905, route de Saran, 45520 Gidy, France
For all questions, please contact the representative office of Servier Laboratories JSC.
Representative office of Servier Laboratories JSC:
115054, Moscow, Paveletskaya sq. d.2, p.3
On the instructions enclosed in the pack, the logo of the Servier Laboratories is additionally indicated.
Registration manager: Irina Kolotushkina
Inflammatory changes in the respiratory mucosa are a fairly common occurrence among children of preschool and school age. Usually, this pathology occurs when various viral and bacterial pathogens enter the body. Therefore, the main task facing pediatricians is to strengthen local protective factors, reduce the manifestations of the mucosal inflammatory reaction, reduce the severity of cough and improve sputum drainage. All these effects are promised by the instructions for the use of "Erespal" for children.
An important advantage of this drug is that its anti-inflammatory effect differs from the effect of classical non-steroidal anti-inflammatory drugs or glucocorticoids. Therefore, "Erespal" is devoid of a number of side effects characteristic of these groups of drugs.
The action of the drug
The main active ingredient of "Erespal" is fenspiride hydrochloride. This substance is able to have a complex therapeutic effect on the structures of the respiratory system. Fenspiride has the following effects:
- anti-inflammatory;
- antiallergic;
- stimulates the excretion of mucus.
The anti-inflammatory effect of fenspiride is explained by its ability to reduce the number of inflammatory molecules (prostaglandins, leukotrienes). The antiallergic effect is associated with an effect on specific receptors. Thus, the hyperreactivity of the bronchi decreases and their patency improves.
In what cases is it assigned
Fenspiride hydrochloride selectively affects the upper and lower parts of the respiratory system. Therefore, the range of application of this drug is quite wide. Indications for use are:
- diseases of the upper respiratory tract (sinusitis, otitis media);
- rhinopharyngitis, pharyngitis, adenoids;
- laryngitis;
- bronchitis, tracheobronchitis;
- bronchoasthmatic syndrome;
- dry or wet cough;
- discomfort in the throat with viral infections (ARVI, influenza, measles).
"Erespal" can be included in a comprehensive treatment regimen for various respiratory pathologies. It is successfully used together with antibiotics, expectorants or inhalations. However, before using it, it is still recommended to consult a pediatrician.
Release form
The drug "Erespal" is available in the form of the following pharmaceutical forms:
- syrup;
- pills.
Syrup
Syrup "Erespal" is available in bottles containing 0.15 or 0.25 liters of medication. The content of fenspiride hydrochloride in it is 2 mg per milliliter of the drug. The syrup is a yellowish liquid with a sweet taste and a pleasant vanilla aroma. Children drink this medicine with pleasure, however, it should be remembered that there are additives in its composition. The components of the drug, in addition to fenspiride hydrochloride, are:
- licorice extract;
- vanilla flavor;
- sucrose, saccharin;
- glycerol.
Some components can cause allergic reactions in children predisposed to them. This point should be taken into account when Erespal is prescribed to a newborn or infant who has a tendency to allergies. The presence of sweeteners should be considered in the treatment of patients with diabetes mellitus. It must be remembered that five milliliters of syrup contains 0.3 XE (bread units).
Pills
Erespal tablets contain 0.08 g of fenspiride hydrochloride. They include a minimum number of additional components, however, their use is only allowed in patients who have reached the age of 18 years. Therefore, it is not recommended to give Erespal tablets to children under one year of age or preschool age, and if necessary, you should ask your doctor if this can be done.
How to apply
According to the official instructions, Erespal syrup is allowed to be given to children who have reached the age of two. However, in practice, Erespal is prescribed from the age of three months.
The drug is taken before meals, so its absorption in the gastrointestinal tract improves. Shake the medicine bottle well before use. For young children, syrup can be added to any drink or feeding bottle.
The required amount of "Erespal" is measured using the attached measuring spoon. Dosages are indicated in the table.
Table - Age dosages of "Erespal"
When calculating the dosage, it should be taken into account that one teaspoon contains 5 ml of syrup, and one tablespoon contains 15 ml. The dosage of "Erespal" for children under one year, as a rule, is calculated by the pediatrician individually, depending on the severity of the symptoms and the course of the disease.
Usually, the duration of the use of "Erespal" is seven to eight days, if necessary, therapy is extended to two weeks. How much exactly to give "Erespal" to a child, you should definitely check with your doctor.
Efficiency
According to pediatricians, the effect of the use of this drug is observed already on the second or third day of treatment. In children, nasal discharge, swelling and redness of the pharynx are significantly reduced, and coughing is reduced. Nevertheless, it is not recommended to use this medicine for the prevention of complications in acute respiratory viral infections.
Reviews of "Erespal" for children indicate that it is an effective drug that allows you to eliminate unpleasant symptoms in inflammatory processes in the respiratory tract.
The high efficiency of "Erespal" allows you to use it as a monotherapy. This eliminates the need to prescribe other drugs (anti-inflammatory, expectorant, antihistamines). Thus, the cost of treatment and the risk of side effects from various drugs are significantly reduced.
How is Erespal tolerated by children
Usually children tolerate Erespal well. Occasionally, when taking it, the following side effects occur:
- nausea, rarely vomiting;
- violation of the stool, pain in the abdomen;
- dizziness, sometimes drowsiness;
- increase in heart rate;
- low blood pressure;
- fatigue;
- allergic reactions in the form of skin rashes, itching, rarely - Quincke's edema.
Extremely rarely, when taking large doses of the drug (more than 2.32 g), overdose phenomena occur. Its symptoms in a child are psychomotor agitation or, conversely, increased drowsiness, vomiting, diarrhea, and frequent pulse. There is no specific antidote for Erespal. Treatment is aimed at accelerating the elimination of the drug from the body and restoring vital functions.
The main contraindication for taking the medicine is individual intolerance to fenspiride hydrochloride and other components of the syrup. Also, the drug is used with caution in children with impaired metabolism of fructose and other sugars.
Acquisition and analogues
"Erespal" for a child refers to an over-the-counter dosage form. It can be freely bought without a doctor's prescription. However, before giving medicine to a baby, it is still recommended to consult a pediatrician about how often Erespal can be taken by a child.
The pharmacy chain also presents analogues of the original drug:
- "Epistat";
- "Siresp";
- "Erisspirus".
These medicines also contain fenspiride hydrochloride as the main active ingredient. They are available in the form of a syrup and can be used to treat young children. The dosage of these drugs is calculated similarly to "Erespal", additional information is given in the instructions enclosed in the package.
The safety of Erespal has been proven in numerous clinical studies, so pediatricians are increasingly prescribing Erespal for infants and preschoolers if they have diseases of the respiratory system.
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